ABSTRACT
Hand, foot and mouth disease (HFMD) is a common acute infectious disease among children. Enterovirus 71 (EV71) is one of the major pathogens of HFMD. The incidence of HFMD in our country is higher, the main target population of infection is infants and young children; EV71 is also the most important pathogen causing severe HFMD in children currently. HFMD was classified as notifiable communicable disease of Category C on May 2, 2008. Pathogenesis of HFMD is not yet clear, and there is no drug that can treat such virus effectively. The non-structural protein 3D in EV71, is one of the important targets for the development of anti-EV71 virus drugs, which catalyzes the replication and transcription of the viral genome. This review provides a summary of the structure and function of EV71 3D, which can provide reference for the development of antiviral drugs.